What does this research mean for the field?

Female Borderline Personality Disorder patients with a history of auditory verbal hallucinations exhibit significantly reduced cortical gyrification in the right transverse temporal gyrus compared to BPD patients without such hallucinations and healthy controls. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

Investigate structural brain differences in auditory and speech processing regions among female patients with borderline personality disorder with and without a lifetime history of auditory verbal hallucinations.

August 30, 2026Brain Structure and FunctionOpen Access

Structural alterations in early auditory cortex in borderline personality disorder with auditory verbal hallucinations

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Authors

YPYéléna Le PrieultHeidelberg University MOMarie‐Luise OtteHeidelberg University MSMike M. SchmitgenHeidelberg University

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Implication

Neuroimaging study reveals reduced cortical gyrification in early auditory cortex in borderline personality disorder with hallucinations, suggesting neurodevelopmental sensory processing deficits.

Key Points

Investigate structural brain differences in auditory and speech processing regions among female patients with borderline personality disorder with and without a lifetime history of auditory verbal hallucinations.
Acquired high-resolution structural MRI scans from 77 female participants: BPD with hallucinations (n=20), BPD without hallucinations (n=27), and healthy controls (n=30).
Measured cortical thickness, cortical gyrification, and gray matter volume across frontotemporal regions of interest using CAT12 and SPM12, supplemented by Heschl's gyrus segmentation with the TASH toolbox.
Patients with BPD and auditory verbal hallucinations demonstrated significantly reduced cortical gyrification in the right transverse temporal gyrus compared with both healthy controls and hallucination-free BPD patients.
No statistically significant group differences emerged across other evaluated regions of interest for gray matter volume, cortical thickness, or cortical gyrification.

Cite This Study

Prieult et al. (2026) studied this question.

synapsesocial.com/papers/6a93f08e6c1a8fb52e79cc89 https://doi.org/10.1007/s00429-026-03162-0

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Implication

Neuroimaging study reveals reduced cortical gyrification in early auditory cortex in borderline personality disorder with hallucinations, suggesting neurodevelopmental sensory processing deficits.

Structural alterations in early auditory cortex in borderline personality disorder with auditory verbal hallucinations

Discussion

Member takes

Implication

Key Points

Cite This Study

Structural alterations in early auditory cortex in borderline personality disorder with auditory verbal hallucinations

Discussion

Member takes

Implication

Key Points

Cite This Study

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