Pyrido[2′,1′:2,3]imidazo[4,5- c ]quinolines (PIQs) were prepared from 2-(2-bromophenyl)imidazo[1,2- a ]pyridines, NH 3 and DMSO via a tandem process including CuI/ l -proline-catalysed C–N coupling and aerobic oxidative cyclization steps.
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Do et al. (2025) studied this question.
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