Observed pyroptosis reduces oocyte maturation in polycystic ovary syndrome, suggesting targets for improvement.
High androgen induced pyroptosis of ovarian granulosa cells in a mouse model of PCOS, leading to ER stress in oocytes and a decrease of the oocyte maturation rate. Effective alleviation of granulosa cell pyroptosis can inhibit ER stress in oocytes and improve their maturation rate. This study provides new therapeutic targets for improving oocyte maturation in PCOS.
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Xianguo Xie (2025) studied this question.
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