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Method reveals in vitro antiglycation activity of N-hydroxybenzoyl derivatives in synthesis applications, indicating potential therapeutic uses.
A method was developed for a one-pot multicomponent synthesis of N-hydroxybenzoyl derivatives of 5-methyl-1,2-oxazol-3-amine by the Schotten–Baumann reaction (Einhorn method) by carrying out successive reactions without isolating intermediate products: the reaction of chlorides of hydroxybenzoic acids or their functional derivatives with aminoisoxazole at room temperature in methylene chloride at pH = 8–9. The structures of the obtained compounds were confirmed by H and C NMR spectroscopy data. Significant antiglycation activity of some target compounds was revealed in vitro testing.
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A. K. BREL' (2025) studied this question.
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