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December 2, 2025BMC Sports Science Medicine and Rehabilitation7 citationsOpen Access

Exercise as a modulator of systemic inflammation and oxidative stress biomarkers across clinical and healthy populations: an umbrella meta-analysis

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WFWei FengYWYanzhong WangXGXin Gu

Key Points

  • Exercise significantly decreases IL-6 levels, suggesting an essential role in managing systemic inflammation.
  • Overall, analysis combines data from numerous studies to strengthen evidence on exercise benefits.
  • Assessment of systemic inflammation and oxidative stress biomarkers across different populations establishes broad relevance.
  • Findings underscore the potential of exercise as a simple intervention against inflammation-related health issues.

Abstract

Exercise program could attenuate the CRP, IL-6, IL-8 and TNF-α level. Additionally, exercise demonstrated a beneficial impact on oxidative status, as evidenced by decreased MDA levels and increased GPx activity.

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Cite This Study

Feng et al. (2025) studied this question.

synapsesocial.com/papers/692e3d8d6c9b3ab28c187787https://doi.org/10.1186/s13102-025-01327-8
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