Ultrasonic Synthesis of Poly(Aniline‐Co‐Pyrrole)/ β ‐Cyclodextrin Nanocomposite: A Promising Drug Delivery System

This study presents the ultrasound‐assisted synthesis of a poly(aniline‐co‐pyrrole) (PANI‐co‐PPy) nanocomposite incorporating β ‐cyclodextrin ( β ‐CD) for potential applications in drug delivery systems. The synthesized nanocomposites were systematically characterized using spectral, morphological, and thermal analyses. Fourier‐transform infrared (FTIR) spectroscopy confirmed the successful formation of the nanocomposites, revealing electrostatic interactions between β ‐CD and the PANI‐co‐PPy copolymer. X‐ray diffraction (XRD) analysis further validated the crystalline structure of the nanocomposites and confirmed the intercalation of PANI‐co‐PPy within the β ‐CD matrix. UV‐visible spectroscopy provided additional evidence supporting the copolymerization and intercalation processes. Thermogravimetric analysis (TGA) demonstrated the thermal stability of the nanocomposites, confirming the successful incorporation of PANI and PPy. Ciprofloxacin (CIP) was employed as a model drug to evaluate the drug‐loading and release behavior of the nanocomposites. In vitro drug release studies were performed in simulated intestinal fluid at pH 7.4, with the β ‐CD/PANI‐co‐PPy/30‐70 and β ‐CD/PANI‐co‐PPy/70‐30 formulations exhibiting drug release efficiencies of approximately 65% and 85%, respectively, over a period of 6 h at 37°C. The drug release kinetics followed a zero‐order model with parabolic diffusion characteristics, indicating a controlled and sustained release mechanism. These findings highlight the potential of β ‐CD/PANI‐co‐PPy nanocomposites as effective drug delivery carriers for antibiotics such as CIP.