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June 20, 2026Carbohydrate Polymer Technologies and ApplicationsOpen Access

Coaxial PCL-Core/PVA–Silk Fibroin-Shell Nanofibers for Sustained Ciprofloxacin Delivery and Antibacterial Activity: Direct Loading versus Chitosan Nanoparticle-Mediated Delivery

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Authors

AAmanullahMIMd Mainul IslamMRMd. Mustafizur Rahman

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Overview

Randomized trial compares direct loading and chitosan-mediated delivery of ciprofloxacin in nanofibers, suggesting improved antibiotic release and efficacy.

Key Points

  • This research aims to develop coaxial nanofibers for ciprofloxacin delivery and compare the effectiveness of direct loading versus chitosan nanoparticle-mediated strategies.
  • Developed coaxial PCL-core/PVA-SF-shell nanofibers using two ciprofloxacin delivery methods: direct loading and chitosan encapsulation.
  • Evaluated properties such as fiber diameter, moisture management, antibacterial activity, thermal stability, and tensile strength.
  • Measured drug release profiles and cell viability over time.
  • Nanoparticle-mediated delivery created fibers with a diameter of 178 nm, enhancing uniformity.
  • The sustained ciprofloxacin release rate was improved to 94% over 70 hours compared to 85% in 10 hours for direct loading.
  • Antibacterial activity increased, achieving a 40 mm zone against E. coli, along with high cell viability (>90%).

Cite This Study

Amanullah et al. (2026) studied this question.

synapsesocial.com/papers/6a362de1db0793dc1a535e8fhttps://doi.org/10.1016/j.carpta.2026.101184
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Coaxial PCL/Gelatin Nanofibers Integrated with Chitosan Hydrogel for Controlled Drug Delivery and Antibacterial Applications2026
  2. 2Antibacterial Electrospun Membrane with Hierarchical Bead-on-String Structured Fibres for Wound Infections2024 · 4 citations
  3. 3Chitosan–zinc oxide nanocomposite as an efficient carrier for ciprofloxacin with enhanced antibacterial activity2026
  4. 4Fabrication and Assessment of Quorum Sensing Inhibitor Enhanced Ciprofloxacin <scp>HCl</scp> Nanoparticles for Anti‐Biofilm Ocular Drug Delivery2025
  5. 5Nanostructured Lipid Carriers Enhance Ciprofloxacin Antibacterial Activity Through Diffusion-Controlled Release and Modulation of Bacterial Growth Kinetics2026