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December 8, 2025Journal of Applied Polymer Science

Fabrication and Assessment of Quorum Sensing Inhibitor Enhanced Ciprofloxacin HCl Nanoparticles for Anti‐Biofilm Ocular Drug Delivery

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Authors

AVAmber VyasPandit Ravishankar Shukla University

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Overview

In vitro analysis revealed enhanced antimicrobial efficacy in Pseudomonas aeruginosa biofilms using ciprofloxacin HCl nanoparticles, indicating new therapeutic strategies for ocular infections.

Key Points

  • Antimicrobial efficacy improved via quorum sensing inhibition and nanoparticle formulation in ocular treatment.
  • Characterization showed that optimized nanoparticles had a size of 53.24 nm and high entrapment efficiency of 88.02%.
  • Evaluation included crystal violet assay for biofilm inhibition and fluorescence microscopy to assess biofilm disruption.
  • This formulation offers potential solutions to combat antibiotic resistance in ocular infections caused by Pseudomonas aeruginosa.

Cite This Study

Amber Vyas (2025) studied this question.

synapsesocial.com/papers/69401f142d562116f28fa5a3https://doi.org/10.1002/app.70102
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Also Consider

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  1. 1Glycol Chitosan-Poly(lactic acid) Conjugate Nanoparticles Encapsulating Ciprofloxacin: A Mucoadhesive, Antiquorum-Sensing, and Biofilm-Disrupting Treatment Modality for Bacterial Keratitis2024 · 23 citations
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