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June 27, 2026BMC MicrobiologyOpen Access

Enhanced antibiofilm activity of ciprofloxacin-loaded quatsomal gel against Multidrug-Resistant Staphylococcus aureus (MRSA)

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Authors

JSJianguo ShiZFZanib FaridSASanaa Anjum

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Overview

Randomized trial evaluates enhanced antimicrobial efficacy of quatsomal gel in MRSA infections, suggesting a novel treatment option.

Key Points

  • This study aims to enhance the antimicrobial and antibiofilm activity of ciprofloxacin against MRSA using quatsomal gel.
  • Ciprofloxacin-loaded quatsomes were prepared using probe-sonication with CTAB and cholesterol.
  • An in vivo wound excision model in mice was employed to assess therapeutic efficacy.
  • Formulation characterization included particle size, zeta potential, and drug entrapment efficiency.
  • The optimized formulation achieved a mean particle size of 153 ± 1.3 nm and 79 ± 0.4% entrapment efficiency.
  • Ciprofloxacin-loaded quatsomes resulted in 91.32 ± 0.14% biofilm inhibition and a 98% wound contraction rate.
  • Compared to the ciprofloxacin treated group, which had 82% wound contraction and ~ -1.8 log 10 CFU reduction.

Cite This Study

Shi et al. (2026) studied this question.

synapsesocial.com/papers/6a3f67aaaea7db3c1953efc7https://doi.org/10.1186/s12866-026-05326-8
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