Enhanced antibacterial, antibiofilm, and antioxidant potential of ciprofloxacin-loaded SDS-capped silver nanoparticles against resistant bacterial strains
The study demonstrates improved antibacterial and antibiofilm activity of ciprofloxacin-loaded nanoparticles against resistant bacteria, suggesting a new treatment option.
Key Points
The aim is to evaluate the antimicrobial activity of ciprofloxacin-conjugated silver nanoparticles against resistant bacterial strains.
Ciprofloxacin was conjugated to SDS-capped silver nanoparticles.
Antibacterial activity was assessed against Gram-negative and Gram-positive resistant bacteria.
Morphological and structural characterizations were performed using UV-visible spectroscopy, FTIR, and SEM.
MIC and MBC values were determined to quantify antimicrobial potency.
Cip-SDS-AgNPs showed the largest inhibition zones against E. coli (28mm), P. aeruginosa (25mm), S. aureus (32mm), and L. monocytogenes (37mm).
Cip-SDS-AgNPs had the highest anti-biofilm activity and 85% antioxidant scavenging at 100 ug/mL.
P. aeruginosa had the lowest MIC at 25 ug/mL and MBC at 50 ug/mL, indicating high susceptibility.