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June 20, 2026Materials Today CommunicationsOpen Access

Coaxial PCL/Gelatin Nanofibers Integrated with Chitosan Hydrogel for Controlled Drug Delivery and Antibacterial Applications

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Authors

AAmanullahMIMd. Moinul IslamMRMd. Mustafizur Rahman

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Overview

Randomized trial demonstrates effective drug delivery and antibacterial properties in advanced biomaterials, suggesting improved treatment options.

Key Points

  • The aim is to develop a nanofiber-hydrogel composite for effective drug delivery and antibacterial applications.
  • Coaxial electrospinning was used to fabricate PCL/gelatin nanofibers integrated with chitosan hydrogel.
  • Characterization involved SEM, FTIR, and TGA to assess structural and physicochemical properties.
  • Cytotoxicity testing was performed to evaluate biocompatibility.
  • The composite achieved a sustained drug release of 73% over 120 h.
  • Antibacterial activity showed inhibition zones of approximately 51 mm for Staphylococcus aureus and 35 mm for Escherichia coli.
  • High cell viability (over 93%) indicated good biocompatibility.

Cite This Study

Amanullah et al. (2026) studied this question.

synapsesocial.com/papers/6a362d32db0793dc1a5359d5https://doi.org/10.1016/j.mtcomm.2026.115566
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