December 2, 2025Parasites & VectorsOpen Access

Metarhizium pingshaense infection reverses insecticide resistance in Anopheles gambiae sensu lato by altering energy reserves and gene expression

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Discussion

Fungal infection reduces insecticide resistance and impacts energy reserves in Anopheles gambiae, indicating potential in malaria control.

Metarhizium pingshaense infection reduces survival in resistant An. gambiae mosquitoes, impacting physiological functions.
Resistance testing showed that deltamethrin significantly lessened survival rates in Metarhizium-infected mosquitoes.
Assessment using insecticide susceptibility tests revealed alterations in gene expression, affecting metabolic and immune genes.
The findings suggest integrating biopesticides like Metarhizium alongside traditional insecticides for better malaria control strategies.

Lamy et al. (2025) studied this question.

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Fungal infection reduces insecticide resistance and impacts energy reserves in Anopheles gambiae, indicating potential in malaria control.