What question did this study set out to answer?

To evaluate whether insecticide-resistant Anopheles mosquitoes remain susceptible to entomopathogenic fungi and assess whether fungal pre-infection alters phenotypic insecticide resistance.

September 25, 2009Proceedings of the National Academy of SciencesOpen Access

Fungal infection counters insecticide resistance in African malaria mosquitoes

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Authors

MFMarit FarenhorstHumanTotalCare (Netherlands)JMJoel MouatchoUniversity of Pretoria CKChristophe K. KikankieUniversity of the Witwatersrand

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Implication

Experimental study demonstrates that entomopathogenic fungal infection restores chemical insecticide susceptibility in resistant Anopheles mosquitoes, highlighting a synergistic vector control...

Key Points

To evaluate whether insecticide-resistant Anopheles mosquitoes remain susceptible to entomopathogenic fungi and assess whether fungal pre-infection alters phenotypic insecticide resistance.
Exposed four Anopheles mosquito strains with high resistance to pyrethroids, organochlorines, or carbamates to the entomopathogenic fungus Beauveria bassiana alongside baseline control strains.
Assessed post-infection mosquito survival and quantified changes in mortality following subsequent exposure to permethrin and dichlorodiphenyltrichloroethane (DDT) after pre-infection with B. bassiana or Metarhizium anisopliae.
Insecticide-resistant Anopheles strains were equally susceptible to B. bassiana infection as non-resistant baseline counterparts, exhibiting significantly reduced survival.
Pre-infection with B. bassiana or M. anisopliae significantly increased mosquito mortality upon exposure to permethrin and DDT compared to uninfected controls, indicating reversal of insecticide resistance.

Cite This Study

Farenhorst et al. (2009) studied this question.

synapsesocial.com/papers/69e05a6c46ce12fc615574ab https://doi.org/10.1073/pnas.0908530106

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Implication

Experimental study demonstrates that entomopathogenic fungal infection restores chemical insecticide susceptibility in resistant Anopheles mosquitoes, highlighting a synergistic vector control...

Fungal infection counters insecticide resistance in African malaria mosquitoes

Discussion

Member takes

Implication

Key Points

Cite This Study

Fungal infection counters insecticide resistance in African malaria mosquitoes

Discussion

Member takes

Implication

Key Points

Cite This Study

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