Case report shows high-altitude pulmonary edema and its link to acute mountain sickness, highlighting the role of acetazolamide as prophylaxis.
High-altitude pulmonary edema (HAPE) is a life-threatening altitude illness that usually occurs in insufficiently acclimatized climbers at altitudes above 2500 m. HAPE also accounts for the high-altitude-related mortality among all high-altitude sicknesses. The risk of developing HAPE increases with increasing altitude and faster ascent. Medications, such as acetazolamide, have been recommended as prophylaxis for acute mountain sickness; however, its role in HAPE prevention has not been established.
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Cheng et al. (2025) studied this question.
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