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Methotrexate toxicity and intolerance in paediatric inflammatory bowel disease: A retrospective cohort study

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Retrospective cohort study found high incidence of adverse events from methotrexate in pediatric IBD, highlighting risk factors.

Methotrexate toxicity occurred in 41% of pediatric IBD patients, primarily mild cases.
Hepatotoxicity in 41% and myelotoxicity in 21% are notable adverse events from treatment with methotrexate.
Retrospective cohort analysis evaluated data from 207 patients at a single medical center between 2010 and 2023.
These findings suggest significant risk factors for adverse events related to methotrexate in pediatric IBD patients.

Boer et al. (2025) studied this question.

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