What question did this study set out to answer?

This research aims to examine the association between methotrexate dosage and related toxicities in pediatric patients with malignancy.

March 1, 2026Educational Research Advances

Methotrexate-Induced Toxicities in Pediatrics with Malignancy: A Systematic Review and Meta-analysis

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Authors

AMAmal Saki Malehi FRFakher RahimOsh State University SGSomayeh GharibiMashhad University of Medical Sciences

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Implication

Meta-analysis reveals the impact of methotrexate dosage on toxicity types in pediatric malignancy patients, suggesting treatment adjustments may improve outcomes.

Key Points

This research aims to examine the association between methotrexate dosage and related toxicities in pediatric patients with malignancy.
Systematic review and meta-analysis of 63 studies
Evaluated the prevalence of various methotrexate-induced toxicities
Analyzed the relationship between methotrexate dosage and toxicity types
Mucositis had the highest prevalence of toxicity (P=0.3, 95% CI (0.21, 0.4))
Hepatic toxicity was next (P=0.25, 95% CI (0.18, 0.32))
Hematologic toxicity showed a prevalence of P=0.42 (95% CI (0.25, 0.6))
Dermal toxicity had the lowest prevalence (P=0.17, 95% CI (0.07, 0.28))
Higher toxicity was observed at a 12 mg methotrexate dose compared to other dosages.

Cite This Study

Malehi et al. (2023) studied this question.

synapsesocial.com/papers/69a3d8a7ec16d51705d2faec https://doi.org/10.32598/ijmtfm.vi.39863

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Implication

Meta-analysis reveals the impact of methotrexate dosage on toxicity types in pediatric malignancy patients, suggesting treatment adjustments may improve outcomes.

Methotrexate-Induced Toxicities in Pediatrics with Malignancy: A Systematic Review and Meta-analysis

Discussion

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Implication

Key Points

Cite This Study

Methotrexate-Induced Toxicities in Pediatrics with Malignancy: A Systematic Review and Meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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