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December 4, 2025Biotechnology and Applied BiochemistryOpen Access

Transient Transfection of Rolling‐Circle Amplified DNA in Biomanufacturing‐Relevant Mammalian Cell Lines: A Comparison of Transfection Conditions for Optimal Protein Expression

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Authors

ELEvelina LoghinNHNathan E. Hudson

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Overview

Comparative analysis demonstrates improved monoclonal antibodies production in CHO cells using cationic polymer transfection.

Key Points

  • Monoclonal antibodies production increased significantly in CHO cells with optimal transfection conditions.
  • Cationic polymer reagents showed better efficiency for RCA DNA delivery compared to other agents.
  • Assessment of transfection workflows across two mammalian cell lines highlights significant variability in outcomes.
  • Findings suggest that RCA DNA may effectively replace plasmid for high-titer antibody production in biomanufacturing.

Cite This Study

Loghin et al. (2025) studied this question.

synapsesocial.com/papers/6930dc5fea1aef094cca1debhttps://doi.org/10.1002/bab.70100
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Also Consider

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  1. 1Rolling circle amplification for next-generation molecular diagnostics, genome analysis, and spatial transcriptome profiling2025
  2. 2Autonomous Exponential Amplification via Rolling Circle–DNAzyme Feedback Programming2025
  3. 3Autonomous Exponential Amplification via Rolling Circle–DNAzyme Feedback Programming2025
  4. 4Structural and Kinetic Profiling of Rolling Circle Amplification via Solid-State Nanopore Sensing Using miR-21 as a Model2025
  5. 5Rolling Circle Amplification Boosts Ultrasensitive Liquid Biopsy.2025