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December 4, 2025Advanced ScienceOpen Access

Type I Interferon Pathway Activation Disrupts Monocyte Maturation and Enhances Immune Evasion in Multiple Myeloma

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Authors

JCJian CuiXLXiaoyun LiLWLina Wang

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Overview

Single-cell RNA sequencing reveals Type I interferon activation enhances immune evasion in multiple myeloma, suggesting a therapeutic target.

Key Points

  • Tumor progression is enhanced by Type I Interferon activation within the immune microenvironment in multiple myeloma, impacting monocyte maturation.
  • Single-cell RNA sequencing shows marked transcriptional alterations in monocytes from multiple myeloma patients when compared to healthy donors.
  • Co-culture assays demonstrated that IFN-mediated monocyte reprogramming promotes multiple myeloma cell proliferation, implicating immune dysregulation.
  • Therapeutic targeting of the Interferon signaling pathway may restore anti-tumor immunity in patients with multiple myeloma.

Cite This Study

Cui et al. (2025) studied this question.

synapsesocial.com/papers/6930dc6bea1aef094cca1f6chttps://doi.org/10.1002/advs.202510816
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of potential immune-related mechanisms related to the development of multiple myeloma2024 · 4 citations
  2. 2Multi-omics reveals immune features in immune and non-immune cells, an IFN-γ/IFN-α-B2M positive feedback loop, and targeted metabolic therapy in multiple myeloma2025
  3. 3Single-cell profiling reveals MIF-mediated immune evasion and CD8 + T cell exhaustion in relapsed multiple myeloma2026 · 2 citations
  4. 4Multi-omics reveals immune features in immune and non-immune cells, an IFN-γ/IFN-α-B2M positive feedback loop, and targeted metabolic therapy in multiple myeloma2025
  5. 5Longitudinal profiling of tumor and immune compartments uncovers patterns of dysregulation and associations with response in multiple myeloma2025