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December 4, 2025Journal of Oleo ScienceOpen Access

Development of Turmeric Oil-based 5-Fluorouracil Loaded Lipid Nanogel for Improved Dermatokinetic and Drug Deposition for Skin Cancer

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Authors

MAMohammed W. Al-Rabia

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Overview

Formulation improves skin permeation of 5-fluorouracil, suggesting potential in topical applications for skin cancer.

Key Points

  • Improved skin permeation noted with the 5FL-LNG formulation, enhancing dermatokinetics and drug delivery.
  • Central composite design optimized a formulation featuring a 70:30 mixture of turmeric oil and labrasol.
  • Utilizing lipid-based nanocarriers enables superior entrapment efficiency and stability for topical applications.
  • Significant pre-clinical and clinical studies may further establish the efficacy and safety of the developed nanogel system.

Cite This Study

Mohammed W. Al-Rabia (2025) studied this question.

synapsesocial.com/papers/6930dc6bea1aef094cca201chttps://doi.org/10.5650/jos.ess25076
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Also Consider

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  1. 1Rational Design and Characterization of 5-Fluorouracil-Loaded Lipid-Polymer Hybrid Nanoparticles for Enhanced Transdermal Delivery in Skin Cancer Therapy.2026
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  4. 4Design, statistical optimization, and characterization of Esculin-loaded transliposome nanogel for topical delivery: In-vitro, ex vivo study and dermatokinetic evaluation2024 · 4 citations
  5. 5Liposomal and Micellar-Based Nanoformulations of Fluorinated Curcumin Derivative and Naringenin—Comparative Studies2026