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February 14, 2026Drug Development and Industrial Pharmacy

Ultra-Stabilized Transethosomal Gel for Co-Delivery of 5-Fluorouracil and Carvedilol: Cytotoxicity and In-vivo studies in Skin Cancer

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Authors

PSPrafull ShindeAPAmit Page

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Overview

Cytotoxicity and in-vivo studies reveal improved tumor suppression in skin cancer, indicating a novel treatment strategy.

Key Points

  • This study aims to develop a novel gel for co-delivery of 5-fluorouracil and carvedilol to enhance skin cancer therapy.
  • Developed FU-CVD-loaded transethosomes using various materials.
  • Characterized vesicles using TEM, SEM, and AFM.
  • Evaluated gel for rheology, dermatokinetics, and cytotoxicity in HaCaT cells.
  • Conducted in vivo studies in Wistar rats for dermal deposition and tumor suppression.
  • FU-CVD-TEs demonstrated high entrapment efficiency and sustained release kinetics.
  • The hybrid gel improved ROS generation, induced G1-phase arrest, and significantly reduced IC50.
  • In vivo experiments showed enhanced dermal deposition and strong tumor suppression with good skin safety compared to traditional treatments.

Cite This Study

Shinde et al. (2026) studied this question.

synapsesocial.com/papers/699010942ccff479cfe56ef7https://doi.org/10.1080/03639045.2026.2628014
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  5. 5Optimized Beta-Sitosterol Transethosomal Gel OutperformsTransferosomes for Enhanced Transdermal Delivery and Cytotoxicity inBreast Cancer Therapy2026