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December 4, 2025NAR Molecular MedicineOpen Access

Genome-wide evolutionary selection pressures acting on Pseudomonas aeruginosa residing in different environments

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Authors

PHPok-Man HoRNRahan Rudland NazeerMWMartin Welch

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Overview

Analysis shows significant differences in negative selection of enzymes in cystic fibrosis isolates compared to environmental strains, highlighting specific evolutionary pressures.

Key Points

  • Differential negative selection observed in Pseudomonas aeruginosa isolates from cystic fibrosis and environmental sources, indicating niche adaptation.
  • Key finding: 206 ORFs in cystic fibrosis and environmental isolates exhibit distinct evolutionary pressures, linking selection signatures to enzyme function early.
  • Functional analysis reflected significant enrichment in enzymes at metabolic branchpoints, suggesting critical roles in survival within the cystic fibrosis environment.
  • Correlating gene loss of the psl biosynthetic gene cluster with mutations in mucA may indicate evolutionary strategies for alginate production increase.

Cite This Study

Ho et al. (2025) studied this question.

synapsesocial.com/papers/6930dc78ea1aef094cca218fhttps://doi.org/10.1093/narmme/ugaf040
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genome-wide evolutionary selection pressures acting on <i>Pseudomonas aeruginosa</i> residing in different environments2025
  2. 2Proteomic Analysis of Three Independent Series of Sequential Cystic Fibrosis Strains in an International Pseudomonas aeruginosa Reference Panel Indicates Positive Selection in Late Infection Strains2026
  3. 3Genomic diversity and adaptive resistance mechanisms in <i>Pseudomonas aeruginosa</i> from bronchiectasis2025
  4. 4Protein functional domain analysis enhances genotype–phenotype associations in comparative genomic studies of Pseudomonas aeruginosa2025
  5. 5Genomic Analysis of Antimicrobial Resistance in Pseudomonas aeruginosa from a “One Health” Perspective2024 · 6 citations