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December 4, 2025NAR Molecular MedicineOpen Access

Genome-wide evolutionary selection pressures acting on Pseudomonas aeruginosa residing in different environments

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Authors

PHPok-Man HoRNRahan Rudland NazeerMWMartin Welch

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Implication

Analysis reveals negative selection in Pseudomonas aeruginosa from cystic fibrosis, suggesting functional adaptation in enzymes.

Key Points

  • Cystic fibrosis isolates show a pronounced negative selection pressure, indicating conservation of key genes.
  • Key analysis focused on dN/dS ratios for open reading frames in environmental versus CF-associated strains.
  • Functional analysis highlighted enzymes with metabolic relevance, showing differential selection in various niches.
  • Findings may indicate adaptive strategies in Pseudomonas aeruginosa, particularly in the CF environment.

Cite This Study

Ho et al. (2025) studied this question.

synapsesocial.com/papers/6930e8e3ea1aef094cca407chttps://doi.org/10.1093/narmme/ugaf040
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Also Consider

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  1. 1Genome-wide evolutionary selection pressures acting on Pseudomonas aeruginosa residing in different environments2025 · 1 citations
  2. 2Proteomic Analysis of Three Independent Series of Sequential Cystic Fibrosis Strains in an International Pseudomonas aeruginosa Reference Panel Indicates Positive Selection in Late Infection Strains2026
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  5. 5Genomic Analysis of Antimicrobial Resistance in Pseudomonas aeruginosa from a “One Health” Perspective2024 · 6 citations