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December 4, 2025Journal of Food Science

Exploring Interactions of Volatile Constituents From Polygonum multiflorum With Inflammation‐Related Targets via Dual‐Ligand Docking and MD Simulations

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Authors

WWWei WangZSZuwei SongYCYe Chen

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Overview

Exploratory analysis shows anti-inflammatory properties in RAW 264.7 macrophages, indicating network pharmacology may aid natural product research.

Key Points

  • Nitric oxide was significantly reduced in LPS-stimulated RAW 264.7 macrophages, highlighting the anti-inflammatory properties of Polygonum multiflorum extract.
  • Findings reveal that key core compounds interact with inflammation-related targets like ESR1, FASN, and NR1H3.
  • This study utilized a combination of molecular docking and molecular dynamics simulations to analyze the binding interactions of constituents.
  • Results underscore the importance of network pharmacology in developing effective natural product strategies for managing inflammation.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/6930dc78ea1aef094cca2209https://doi.org/10.1111/1750-3841.70708
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anti-Inflammatory and Analgesic Properties of Polygonum minus: Mechanistic Insights and Therapeutic Potential2026
  2. 2Exploring the Constituents and Mechanisms of <i>Polygonum multiflorum</i> Thunb. in Mitigating Ischemic Stroke: A Network Pharmacology and Molecular Docking Study2024
  3. 3Hepatotoxic Compounds and Mechanisms of Polygonum Multiflorum: A Narrative Review of Recent Advances2026
  4. 4Investigating the enhancing effects of traditional processing on the pharmacological and electrochemical functions of <i>Polygonum multiflorum</i> using THSG as a key marker2025
  5. 5Quality and Safety of Polygonum multiflorum Thunb.: Bridging Ancient Processing Wisdom with Modern Scientific Validation2025