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December 4, 2025Pharmacognosy MagazineOpen Access

Critical Review of 1-Deoxynojirimycin (DNJ) 
in Mulberry in Curing Diabetes Mellitus

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Authors

MSM Sivaprakash

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Overview

This critical review highlights therapeutic potential of mulberry's DNJ in diabetes management, showing improved insulin sensitivity and modulating blood sugar levels.

Key Points

  • Natural compound 1-Deoxynojirimycin from mulberry offers promise in managing diabetes mellitus, illustrating its role in treatment.
  • Highlighted α-glucosidase inhibition by DNJ slows carbohydrate digestion, reducing postprandial glucose spikes.
  • Bioavailability and pharmacokinetics suggest moderate absorption, yet formulation advancements enhance therapeutic potential.
  • Insulin sensitivity improvements with DNJ indicate a natural alternative to synthetic drugs, addressing chronic condition challenges.

Cite This Study

M Sivaprakash (2025) studied this question.

synapsesocial.com/papers/6930dc78ea1aef094cca2359https://doi.org/10.1177/09731296251383290
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Therapeutic Prospects of Mulberry-Derived DNJ: A Review2025
  2. 2Insights into the Activities and Usefulness of Deoxynojirimycin and Morus alba: A Comprehensive Review2025 · 14 citations
  3. 3Metabolic Modulation of Type 2 Diabetes Mellitus by 1-Deoxynojirimycin: A Multifaceted Approach2026 · 1 citations
  4. 4Alginate-Based Carriers Loaded with Mulberry (Morus alba L.) Leaf Extract: A Promising Strategy for Prolonging 1-Deoxynojirimicyn (DNJ) Systemic Activity for the Nutraceutical Management of Hyperglycemic Conditions2024 · 3 citations
  5. 5Quantification of 1-deoxynojirimycin content, ?-amylase inhibition activity, and secondary metabolites in four different mulberry accession leaves from Indonesia2025