An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of progesterone in human serum and plasma

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Candidate reference measurement procedure shows high selectivity and precision for progesterone in plasma, indicating reliable hormonal monitoring.

The candidate reference measurement procedure quantifies progesterone accurately in human plasma with selectivity and precision.
Measurements were validated using certified secondary reference materials, ensuring minimal matrix effects within a range of 0.0400–72.5 ng/mL.
Protocol incorporates isotope dilution-liquid chromatography-tandem mass spectrometry and protein precipitation to enhance accuracy.
This method supports hormonal evaluation in clinical settings, offering metrological traceability for individual patient results.

Ibrahim et al. (2025) studied this question.

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Candidate reference measurement procedure shows high selectivity and precision for progesterone in plasma, indicating reliable hormonal monitoring.