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December 4, 2025International Journal of Molecular SciencesOpen Access

Proteomic Exploration of L1CAM+-Extracellular Vesicles from Plasma of Manifest and Prodromal Parkinson’s Disease

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Authors

MXMary XylakiBOBirgit OtteSWSandrina Weber

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Overview

Proteomic analysis reveals differential expression in extracellular vesicles from patients with Parkinson's disease, suggesting potential as biomarkers.

Key Points

  • Biomarkers may discriminate between Parkinson's disease and healthy controls, indicating possible clinical utility.
  • Differential expression identified in 203 out of 2841 proteins, highlighting potential diagnostic pathways.
  • Immunoprecipitation with magnetic beads was employed to isolate L1CAM+-EVs from blood plasma for analysis.
  • Further validation is essential to confirm the utility of blood plasma proteins as biomarkers for Parkinson's disease.

Cite This Study

Xylaki et al. (2025) studied this question.

synapsesocial.com/papers/6930dc81ea1aef094cca252bhttps://doi.org/10.3390/ijms262311564
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