Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 18, 2025Cell Communication and SignalingOpen Access

Transmission Electron Microscopy-based characterization of Extracellular Vesicles from plasma and serum from Parkinson´s Disease patients

View Full Paper
Ask AI
Bookmark
Share

Authors

AWAlexander WeißWayne State UniversityAMAndreas MeißnerInstitute for Human ReproductionFBFanni Annamária BorosFriedrich-Alexander-Universität Erlangen-Nürnberg

Discussion

Loading...

Member takes

Overview

Pilot study compares extracellular vesicles in plasma and serum of Parkinson's patients and healthy controls, suggesting potential biomarkers.

Key Points

  • Significant differences in extracellular vesicle diameter were observed between Parkinson's disease and healthy control groups.
  • Quantification of extracellular vesicles employed transmission electron microscopy and an ImageJ-based algorithm for analysis.
  • L1CAM-positive extracellular vesicles were selectively enriched for detailed examination using specific antibodies.
  • This pilot study aids in the ongoing search for clinical biomarkers for Parkinson's disease, suggesting EV profiling is promising.

Cite This Study

Weiß et al. (2025) studied this question.

synapsesocial.com/papers/68d463db31b076d99fa62dfdhttps://doi.org/10.1186/s12964-025-02383-w
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Proteomic Exploration of L1CAM+-Extracellular Vesicles from Plasma of Manifest and Prodromal Parkinson’s Disease2025
  2. 2Detection and Profiling of Neurodegenerative Disease-Related Extracellular Vesicles through Membrane and Cargo Proteins2026
  3. 3Investigation of Extracellular Vesicles in Plasma Samples: A Sensitive Method for Analysis2026
  4. 4Isolation and quantification of L1CAM‐positive extracellular vesicles on a chip as a potential biomarker for Parkinson's Disease2024 · 24 citations
  5. 5Plasma extracellular vesicle synaptic proteins as biomarkers of clinical progression in patients with Parkinson’s disease2024