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April 6, 2026Journal of Advances in Medicine and Medical ResearchOpen Access

Investigation of Extracellular Vesicles in Plasma Samples: A Sensitive Method for Analysis

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Authors

MCMaria Eduarda Cunha-SilvaUniversidade Federal de Santa CatarinaLWLaura Otto WalterUniversidade Federal de Santa CatarinaHCHeloísa Zorzi CostaUniversidade Federal de Santa Catarina

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Implication

Investigation standardizes a method for analyzing extracellular vesicles in plasma, suggesting potential biomarker use.

Key Points

  • This investigation aims to standardize a protocol for isolating and characterizing extracellular vesicles (EVs) from human plasma samples.
  • Standardized protocol for isolating EVs using serial centrifugation.
  • Characterization of EVs performed with conventional flow cytometry.
  • Utilized peripheral blood samples from patients with pro-inflammatory conditions.
  • Demonstrated feasibility of EV enrichment and detection in plasma samples.
  • Enhanced accessibility of EV analysis in laboratories with limited infrastructure.
  • Identified limitations related to sensitivity for particles smaller than 200 nm.

Cite This Study

Cunha-Silva et al. (2026) studied this question.

synapsesocial.com/papers/69d34cee9c07852e0af9728dhttps://doi.org/10.9734/jammr/2026/v38i46112
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Also Consider

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  1. 1High-Efficiency Capture and Proteomic Analysis of Plasma-Derived Extracellular Vesicles through Affinity Purification2024
  2. 2Protocol for SEC-based isolation and characterization of human plasma-derived extracellular vesicles2026
  3. 3Refining Flow Cytometry-based Sorting of Plasma-derived Extracellular Vesicles2025 · 1 citations
  4. 4Multi-omics characterization of highly enriched human plasma extracellular vesicles2024
  5. 5Optimized AF4 combined with density cushion ultracentrifugation enables profiling of high‐purity human blood extracellular vesicles2024 · 33 citations