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December 4, 2025International Journal of Molecular SciencesOpen Access

Gene Polymorphisms Determining Sex Hormone-Binding Globulin Levels and Endometriosis Risk

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Authors

TPT. A. PonomarevaMCMikhail Churnosov

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Overview

Observational analysis found gene polymorphisms impact endometriosis risk in Caucasian women, suggesting SHBG may play a role.

Key Points

  • Endometriosis risk is influenced by gene polymorphisms associated with SHBG levels and interactions among SNPs.
  • The association was highlighted by an odds ratio of 1.91 for the polymorphic locus rs440837, suggesting a significant impact on endometriosis development.
  • Analysis of nine loci from genome-wide association studies reveals interactions affecting pathways like cell proliferation and transcription regulation.
  • Understanding how SHBG-related polymorphisms influence endometriosis could lead to better risk assessment and potential therapeutic targets.

Cite This Study

Ponomareva et al. (2025) studied this question.

synapsesocial.com/papers/6930dc81ea1aef094cca260dhttps://doi.org/10.3390/ijms262311630
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Polymorphic Locus rs780093 of the Gene is Associated with the Risk of Infertility in Endometriosis2025
  2. 2Association of the BAIAP2L1 gene polymorphism with the risk of developing genital endometriosis in combination with uterine fibroids and endometrial hyperplasia2025
  3. 3Sex-Hormone-Binding Globulin Gene Polymorphisms and Breast Cancer Risk in Caucasian Women of Russia2024 · 15 citations
  4. 4A polymorphic variant of rs440837 A>G in the <i>ZBTB10</i> gene is associated with the occurrence of moderately differentiated breast cancer2024
  5. 5Polymorphism of the FSHB Gene Is Associated with Endometrial Hyperplasia2026