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May 9, 2026LifeOpen Access

Polymorphism of the FSHB Gene Is Associated with Endometrial Hyperplasia

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Authors

VCVladimir ChurnosovBelgorod National Research UniversityMCMaria ChurnosovaBelgorod National Research UniversityEREvgeny ReshetnikovBelgorod National Research University

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Implication

Randomized trial uncovers genetic links between sex hormones and endometrial hyperplasia risk in women, suggesting new pathways.

Key Points

  • The research aims to examine how genetic variations related to sex hormone levels affect the risk of developing endometrial hyperplasia.
  • Analyzed data from 1493 women, including 520 with endometrial hyperplasia and 973 controls.
  • Investigated nine SNPs associated with sex hormone levels and their correlation with EH risk.
  • Utilized multilevel SNP interaction models to assess associations.
  • Found two SNPs, rs11031002 (OR = 0.45–0.50) and rs11031005 (OR = 0.05–0.53), linked to lower EH risk.
  • The TT*rs11031002-rs11031005 haplotype increases EH risk by over 2.5 times (OR = 2.84, p = 1 × 10−11).
  • Identified significant SNP interactions in multilevel models, with key roles in pathways linked to hormonal regulation.

Cite This Study

Churnosov et al. (2026) studied this question.

synapsesocial.com/papers/69fed090b9154b0b82877963https://doi.org/10.3390/life16050782
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