Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 4, 2025Analytical Chemistry

Ultrasensitive Profiling of Extracellular Vesicles by a Microbead- and Aptamer-Enhanced Thermophoretic Assay for Monitoring Therapeutic Responses

View Full Paper
Ask AI
Bookmark
Share

Authors

YHYanjuan HuangSZShaohua ZhangJDJinqi Deng

Discussion

Loading...

Member takes

Overview

Microbead-aptamer assay demonstrates a detection limit of 41 EVs/μL in breast cancer, implying enhanced therapeutic monitoring.

Key Points

  • Longitudinal monitoring of therapeutic responses provides critical insights into treatment optimization.
  • The microbead-aptamer-enhanced assay achieves a detection limit of 41 EVs/μL, enabling precise protein profiling.
  • Assessment of tumor-derived extracellular vesicles, including HER2 and other biomarkers, is central to effective treatment monitoring.
  • This innovative approach supports noninvasive methods for tracking cancer therapy responses, highlighting its potential clinical impact.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/6930dc8aea1aef094cca26a7https://doi.org/10.1021/acs.analchem.5c06434
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular Identification of Tumor-Derived Extracellular Vesicles Using Thermophoresis-Mediated DNA Computation2021 · 231 citations
  2. 2Extracellular Vesicles as Mediators of Therapy Resistance in the Breast Cancer Microenvironment2022 · 19 citations
  3. 3Sensitivity of CA 15-3, CEA and serum HER2 in the early detection of recurrence of breast cancer2013 · 71 citations
  4. 4Bispecific Aptamer Chimeras Enable Targeted Protein Degradation on Cell Membranes2021 · 30 citations