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December 4, 2025Molecular Systems BiologyOpen Access

Expansion omics: from expansion microscopy to spatial omics

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Authors

ZDZhen DongTGTiannan Guo

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Overview

This perspective highlights how expansion omics enhances spatial resolution in gene expression, indicating its potential in profiling biomolecules and biological functions.

Key Points

  • Biomolecules and gene expression can be accurately profiled through expansion omics techniques, enabling better spatial resolution.
  • Multi-omics integration is showcased with applications in transcriptomics, proteomics, lipidomics, and epigenomics.
  • Analyzing molecular species in a specific tissue context yields valuable insights into biological functions and chromatin states.
  • Continued advancements in spatial resolution and hydrogel adaptability are critical for scaling data in this evolving field.

Cite This Study

Dong et al. (2025) studied this question.

synapsesocial.com/papers/6930dc92ea1aef094cca292fhttps://doi.org/10.1038/s44320-025-00171-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Expanding horizons: a decade of synergy between light sheet and expansion microscopy2026
  2. 2Expansion microscopy for super-resolution imaging of collagen-abundant tissues2024
  3. 3Spatial omics in 3D culture model systems: decoding cellular positioning mechanisms and microenvironmental dynamics2025
  4. 4Spatial multiomics in biomedical research: advances beyond transcriptomics2026
  5. 5Decoding plant complexity through spatially resolved multi-omics approaches2026 · 5 citations