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December 4, 2025EMBO Molecular MedicineOpen Access

Prediction of continuous amyloid positron emission tomography with fluid measures of phosphorylated tau and β-amyloid

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Authors

NMNiklas MattssonSJShorena JanelidzeOHOskar Hansson

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Overview

Exploratory analysis reveals cerebrospinal fluid and amyloid biomarkers predict Aβ-PET in Alzheimer disease, suggesting early detection.

Key Points

  • Continuous Aβ-PET load shows strong prediction accuracy using CSF and plasma measures, indicating promising diagnostic pathways.
  • Best model achieved R2 of 0.79, revealing significant contributions from plasma P-tau217 and CSF Aβ42/Aβ40 measurements.
  • Analysis relies on biofluid biomarkers from a combined total of 1291 individuals in the BioFINDER-1 and BioFINDER-2 studies.
  • Findings suggest potential for earlier Alzheimer disease detection through continuous monitoring of amyloid pathology.

Cite This Study

Mattsson et al. (2025) studied this question.

synapsesocial.com/papers/6930dc92ea1aef094cca2a73https://doi.org/10.1038/s44321-025-00348-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plasma p-tau217, p-tau181, and Aβ42 predict amyloid PET positivity in cognitively unimpaired adults2026 · 3 citations
  2. 2Plasma biomarker progression across the Alzheimer's disease amyloid beta and tau positron emission tomography trajectories2026 · 1 citations
  3. 3Comparing the predictive value of plasma p-tau217 and CSF biomarkers (p-tau181, Aβ42) using amyloid positron emission tomography in Alzheimer's continuum2025
  4. 4Amyloid probability in Alzheimer disease from plasma, cerebrospinal fluid, and amyloid imaging2026
  5. 5Plasma p-tau217, p-tau181 and Aβ42/40 for Alzheimer’s disease diagnosis: ROC accuracy and 18F-florbetapir amyloid PET-CT concordance2026