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December 4, 2025EMBO Molecular MedicineOpen Access

Corneal biomechanical cues mediated by PAI-2: the origin of PM2.5-induced corneal disease

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Authors

SHShengjie HaoDLDan LiLCLu Chen

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Overview

Observational analysis shows corneal thickness increases due to PM2.5 exposure, indicating corneal biomechanical cues may be key biomarkers for early ocular damage.

Key Points

  • Increased corneal thickness and biomechanical cues are linked to PM2.5 exposure, highlighting disease progression.
  • Key metrics include increased corneal hysteresis and tensile stress observed in human and rat models.
  • Analysis of biomarker responses indicates direct involvement of autophagy and inflammation in ocular injury mechanics.
  • Findings may enable targeted interventions using specific biomarkers for early diagnosis of soft tissue diseases.

Cite This Study

Hao et al. (2025) studied this question.

synapsesocial.com/papers/6930dc92ea1aef094cca2a94https://doi.org/10.1038/s44321-025-00341-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transcriptomic profiling of human corneal epithelial cells exposed to PM2.5: Identification of differentially expressed genes and pathways2026
  2. 2Long-term PM2.5 exposure disrupts corneal epithelial homeostasis by impairing limbal stem/progenitor cells in humans and rat models2023 · 29 citations
  3. 3Analysis of corneal biomechanical characteristics and clinical correlations in children with dust mite-allergic conjunctivitis2026
  4. 4Corneal Biomechanical Changes Induced by Chronic Elevated Intraocular Pressure: Implications for Glaucoma Pathogenesis and Management2025
  5. 5Inflammatory Cytokines and Chemokines Are Synergistically Induced in a ROS-Dependent Manner by a Co-Culture of Corneal Epithelial Cells and Neutrophil-like Cells in the Presence of Particulate Matter2024 · 4 citations