What does this research mean for the field?

Long-term PM2.5 exposure disrupts corneal epithelial homeostasis and impairs limbal stem/progenitor cells through circadian rhythm misalignment and microenvironment disturbance. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

What question did this study set out to answer?

This study aims to investigate how long-term PM2.5 exposure affects limbal stem/progenitor cells (LSPCs) and corneal health.

September 27, 2023Particle and Fibre ToxicologyOpen Access

Long-term PM2.5 exposure disrupts corneal epithelial homeostasis by impairing limbal stem/progenitor cells in humans and rat models

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Authors

SHShengjie HaoHangzhou Medical College ZCZhijian ChenBaptist Hospital of Miami YGYuzhou GuShanghai Clinical Research Center

Discussion

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Implication

Randomized trial shows PM2.5 exposure affects corneal epithelial thickness, suggesting new treatment pathways.

Key Points

This study aims to investigate how long-term PM2.5 exposure affects limbal stem/progenitor cells (LSPCs) and corneal health.
Correlation analysis of PM2.5 exposure and limbal epithelial thickness using Optical Coherence Tomography.
Establishment of long- and short-term PM2.5 exposed rat models to examine changes in LSPCs.
RNA sequencing to analyze circadian gene expression associated with LSPCs.
Residents in high PM2.5 areas showed thinner limbal epithelium, indicating LSPC loss.
Long-term exposure in rats resulted in impaired LSPC differentiation and corneal epithelial defects.
Circadian genes Per1, Per2, Per3, and Rev-erbα were upregulated, linking circadian rhythm disruption to LSPC dysfunction.

Cite This Study

Hao et al. (2023) studied this question.

synapsesocial.com/papers/6a61a77dba6827eff93f6246 https://doi.org/10.1186/s12989-023-00540-y

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September 27, 2023Particle and Fibre ToxicologyOpen Access

Long-term PM2.5 exposure disrupts corneal epithelial homeostasis by impairing limbal stem/progenitor cells in humans and rat models

View Full Paper

Ask AI

Bookmark

Authors

SHShengjie HaoHangzhou Medical College ZCZhijian ChenBaptist Hospital of Miami YGYuzhou GuShanghai Clinical Research Center

Discussion

Member takes

Implication

Randomized trial shows PM2.5 exposure affects corneal epithelial thickness, suggesting new treatment pathways.

Key Points

This study aims to investigate how long-term PM2.5 exposure affects limbal stem/progenitor cells (LSPCs) and corneal health.
Correlation analysis of PM2.5 exposure and limbal epithelial thickness using Optical Coherence Tomography.
Establishment of long- and short-term PM2.5 exposed rat models to examine changes in LSPCs.
RNA sequencing to analyze circadian gene expression associated with LSPCs.
Residents in high PM2.5 areas showed thinner limbal epithelium, indicating LSPC loss.
Long-term exposure in rats resulted in impaired LSPC differentiation and corneal epithelial defects.
Circadian genes Per1, Per2, Per3, and Rev-erbα were upregulated, linking circadian rhythm disruption to LSPC dysfunction.

Cite This Study

Hao et al. (2023) studied this question.

synapsesocial.com/papers/6a61a77dba6827eff93f6246 https://doi.org/10.1186/s12989-023-00540-y

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