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December 4, 2025Immunology

GPR56 Outperforms CD319 as a Discriminative Marker for CD4 + Cytotoxic T Lymphocytes and Is Elevated in Primary Sjögren's Syndrome

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Authors

ABAyibaota BahabayiXZXingyue ZengZZZhonghui Zhang

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Overview

Analysis reveals GPR56 as a significant marker for CD4+ cytotoxic T lymphocytes in autoimmune disorders, suggesting novel therapeutic potential.

Key Points

  • Elevated CD4+ GPR56+ T cells correlate with increased disease severity in primary Sjögren's syndrome, indicating GPR56's role in pathogenesis.
  • CD4+ GPR56+ T cells exhibited enhanced cytotoxicity with high granzyme B expression, thereby supporting their diagnostic potential.
  • Single-cell RNA sequencing and transcriptomic analysis highlighted immune activation pathways in CD4+ GPR56+ T cells, differentiating them from CD4+ GPR56− counterparts.
  • Research suggests GPR56 could serve as a target for therapeutic strategies in autoimmune disorders.

Cite This Study

Bahabayi et al. (2025) studied this question.

synapsesocial.com/papers/6930dc92ea1aef094cca2a9ehttps://doi.org/10.1111/imm.70073
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identifying Negative Biomarkers of CD4 Cytotoxic T Lymphocytes via Granzyme B Exclusion Analysis2026 · 1 citations
  2. 2Heterogeneity of circulating CD57+ cytotoxic cell subsets across disease stage and aggressiveness in cutaneous T cell lymphoma2025
  3. 3OP0154 TLR2 INCREASING CD8+T CELL CYTOTOXICITY BY ACTIVATING MITOPHAGY IN PRIMARY SJOGREN’S SYNDROME2024
  4. 4The proportion of CD161 on CD56<sup>+</sup> NK cells in peripheral circulation associates with clinical features and disease activity of primary Sjögren's syndrome2024 · 6 citations
  5. 5Selective Reduction of <scp>MAIT</scp> Cells in Peripheral Blood T Cell Subsets of Primary Sjögren's Syndrome and Their Clinical Significance2025