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December 4, 2025Biomarker ResearchOpen Access

Mega-scale single-cell profiling reveals novel biomarkers associated with acute GvHD after allogeneic hematopoietic stem cell transplantation

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Authors

ZSZheng SongRDRegine J. DressECEmilia Czajkowski

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Overview

Single-cell profiling reveals novel biomarkers associated with acute GvHD in AML patients, suggesting better risk stratification for hematopoietic stem cell transplantation outcomes.

Key Points

  • Risk stratification for acute GvHD improves with identified biomarkers from single-cell profiling.
  • The study highlights five novel biomarkers linked to graft-versus-host disease in AML patients.
  • Assessment involved mega-scale single-cell profiling of leukocytes in post-transplant follow-up samples.
  • Identified biomarkers may guide therapeutic strategies and improve patient outcomes post-transplant.

Cite This Study

Song et al. (2025) studied this question.

synapsesocial.com/papers/6930dc92ea1aef094cca2b1fhttps://doi.org/10.1186/s40364-025-00868-x
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