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December 8, 2025Blood

Single-cell transcriptional profiling identifies ADGRG1+ CD8 T cells as critical mediators of graft-versus-leukemia effect in AML relapse after haploidentical hematopoietic stem cell transplantation

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Authors

LYLuxin YangSPShanshan PeiYLYi Luo

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Overview

Transcriptional profiling reveals critical role of ADGRG1+ CD8 T cells in GVL effect, suggesting new therapeutic targets for AML relapse.

Key Points

  • This research examines the role of ADGRG1+ CD8 T cells in mediating graft-versus-leukemia effects in AML post-transplant.
  • Collected and cryopreserved bone marrow samples from AML patients post-haplo-HSCT.
  • Conducted single-cell RNA sequencing for transcriptional profiling and TCR repertoire analysis.
  • Performed bioinformatics analyses to map intercellular communication networks.
  • Constructed a single-cell atlas of the bone marrow microenvironment in relapsed post-haplo-HSCT patients.
  • Identified ADGRG1+ CD8 T cells as key players in mediating the GVL effect with robust cytotoxic properties.
  • Revealed patient-specific mechanisms by which AML cells suppress ADGRG1+ CD8 T cell activation.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e291https://doi.org/10.1182/blood-2025-5870
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