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December 4, 2025Lipids in Health and DiseaseOpen Access

The role of adipose tissue in liver fat accumulation: a sex-specific analysis in an exploratory cross-sectional study

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Authors

JTJens J. ThieleHMHans‐Jonas Meyer

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Overview

Exploratory cross-sectional analysis reveals adipose tissue impacts liver fat, suggesting unique regional effects by sex and relevance for diabetes management.

Key Points

  • Hepatic steatosis is associated with visceral and subcutaneous fat depots, particularly in men and women.
  • Regression analysis showed significant associations, particularly for diabetes mellitus and hypercholesterolemia.
  • Assessment using regression analyses highlighted body surface area adjustments for fat contributions to liver fat.
  • Findings suggest potential for using simple measures like skinfold assessments in identifying liver fat risk.

Cite This Study

Thiele et al. (2025) studied this question.

synapsesocial.com/papers/6930dc9eea1aef094cca2d35https://doi.org/10.1186/s12944-025-02809-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sex- and Age-Related Differences in the Contribution of Ultrasound-Measured Visceral and Subcutaneous Abdominal Fat to Fatty Liver Index in Overweight and Obese Caucasian Adults2019 · 26 citations
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  4. 4Association of total and regional fat-to-muscle ratio with the risk of metabolic dysfunction-associated fatty liver disease and other chronic liver diseases2026 · 7 citations
  5. 5Fat Accumulation in the Liver Is Associated with Defects in Insulin Suppression of Glucose Production and Serum Free Fatty Acids Independent of Obesity in Normal Men2002 · 1,079 citations