Head-to-head comparison demonstrates engraftment of gene-edited HSCs in rhesus macaques, implying ADC conditioning may improve safety in HIV treatment.
Key Points
Transplantation with antibody-drug conjugates enabled engraftment of gene-edited hematopoietic stem cells, enhancing treatment efficacy.
Effects were quantified in terms of myeloablation, hematopoietic recovery, and immunosuppression compared to busulfan.
Using a model of rhesus macaques, both tests showed similar recovery times and preserved lymphocyte counts in all groups.
Findings indicate the need for refinement in antibody-based strategies for effective cellular therapy against infectious diseases.