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December 8, 2025BloodOpen Access

Enhancing donor cell engraftment in prenatal hematopoietic stem cell transplantation with novel antibody-drug conjugates

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Authors

WMWalaa MohamedMRMartin RodriguezCDChristopher B. Doering

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Overview

Demonstrates enhanced engraftment levels in donor cells after hematopoietic stem cell transplantation using antibody-drug conjugates, indicating potential for better treatment outcomes.

Key Points

  • To evaluate the efficacy of antibody-drug conjugates in enhancing donor cell engraftment during hematopoietic stem cell transplantation.
  • Developed novel antibody-drug conjugates for selective depletion of immune cells and fetal hematopoietic stem cells.
  • Performed in-utero hematopoietic stem cell transplantation in fetal sheep models.
  • Measured engraftment levels and potential toxicities through flow cytometry and digital PCR.
  • Human donor cell engraftment significantly higher with antibody-drug conjugates compared to controls.
  • GPI-80 showed the highest increase in myeloid cell engraftment.
  • No significant off-target effects or toxicity associated with antibody-drug conjugate treatment.

Cite This Study

Mohamed et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236dabbhttps://doi.org/10.1182/blood-2025-4086
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Refined design of a CD117 antibody-drug conjugate safely and effectively conditions non-human primates for autologous transplant-based gene therapy2025
  2. 2Engraftment of gene-edited hematopoietic stem cells after antibody-drug conjugate conditioning in nonhuman primates2025 · 5 citations
  3. 3Streptavidin-drug conjugates streamline optimization of antibody-based conditioning for hematopoietic stem cell transplantation2024 · 2 citations
  4. 4Non-genotoxic conditioning to increase donor chimerism levels in a mismatched murine transplant model for sickle cell disease2025
  5. 5[211At]Astatine-Based Conditioning with a Humanized CD45 Antibody for Autologous Hematopoietic Stem Cell Gene Therapy2026 · 2 citations