December 4, 2025Journal of physiological investigation.Open Access

C-C Chemokine Receptor 5 Deficiency Impairs Cardiac and Metabolic Homeostasis, Driving Heart Failure with Preserved Ejection Fraction-like Pathophysiology

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PHPo‐Shiuan HsiehNational Defense Medical Center

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Implication

Observational analysis revealed increased apoptosis and metabolic dysregulation in CCR5 knockout mice, indicating a link to heart failure with preserved ejection fraction.

Key Points

Heart failure with preserved ejection fraction was observed in CCR5 deficient mice, characterized by structural and molecular alterations.
Energy expenditure was reduced in CCR5 knockout mice, leading to increased body weight and metabolic dysregulation.
Contractility and calcium-handling proteins were assessed, highlighting significant cardiac deficiencies and altered myofilament responses.
Findings suggest CCR5 is essential for maintaining cardiometabolic homeostasis; further investigations could inform therapeutic strategies.

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Po‐Shiuan Hsieh (2025) studied this question.

synapsesocial.com/papers/6930e8b6ea1aef094cca2fe6 https://doi.org/10.4103/ejpi.ejpi-d-25-00044

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Implication

Observational analysis revealed increased apoptosis and metabolic dysregulation in CCR5 knockout mice, indicating a link to heart failure with preserved ejection fraction.

C-C Chemokine Receptor 5 Deficiency Impairs Cardiac and Metabolic Homeostasis, Driving Heart Failure with Preserved Ejection Fraction-like Pathophysiology

Discussion

Member takes

Implication

Key Points

Cite This Study

C-C Chemokine Receptor 5 Deficiency Impairs Cardiac and Metabolic Homeostasis, Driving Heart Failure with Preserved Ejection Fraction-like Pathophysiology

Discussion

Member takes

Implication

Key Points

Cite This Study

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