Why the study?
Does CCR5 deletion improve LV remodeling post-myocardial infarction in mice?
Population
Wild-type (WT, n = 25) and CCR5 null (n = 33) mice post-myocardial infarction
Comparison
CCR5 deletion (CCR5 null mice) vs Wild-type (WT) mice
Design
Preclinical
Follow-up
7 days
Authors
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CCR5 deletion worsens post-MI LV remodeling in mice; leaves open any role in human cardiac repair.
Does CCR5 deletion improve LV remodeling post-myocardial infarction in mice?
CCR5 deletion impairs LV remodeling post-myocardial infarction by hindering macrophage activation and stimulating an imbalance in collagen metabolism.
Zamilpa et al. (2011) studied this question.
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