December 4, 2025PeerJOpen Access

Identification of candidate long non-coding RNAs and mRNAs associated with heart aging in mice

View Full Paper

Ask AI

Bookmark

Authors

Discussion

Analysis identifies long non-coding RNAs and mRNAs associated with cardiac aging in C57BL/6 mice, suggesting potential targets for intervention.

Cardiac aging is marked by increased myocardial fibrosis and apoptosis, alongside changes in gene expression.
Aged C57BL/6 mice exhibited significant alterations in cardiac structure and function, notably increased fibrosis.
Transcriptomic profiling using microarrays revealed differentially expressed long non-coding RNAs and mRNAs.
These findings highlight possible regulatory targets for diagnosing and treating age-related heart disease.

Kuai et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark

Analysis identifies long non-coding RNAs and mRNAs associated with cardiac aging in C57BL/6 mice, suggesting potential targets for intervention.