Key result
Gene expression profiling of aged mouse cardiac myocytes revealed decreased cellular adaptation, reduced mitochondrial electron transport activity, and similarities with known heart disorders.
Why the study?
What are the gene expression changes underlying the aging-related decline in cardiac muscle function in mouse ventricular cardiomyocytes?
Population
Apparently healthy young and aged mouse ventricular cardiac muscle cells
Comparison
Gene expression profiling (cDNA libraries) vs Young vs aged mouse ventricular cardiac muscle…
Design
Preclinical
Authors
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Identifies candidate pathways for murine cardiac aging; hypothesis-generating and leaves open human translation or therapeutic relevance.
What are the gene expression changes underlying the aging-related decline in cardiac muscle function in mouse ventricular cardiomyocytes?
Gene expression profiling of aging mouse cardiomyocytes reveals reduced mitochondrial function and stress adaptation, providing molecular insights into age-related contractile dysfunction.
Natalya D. Bodyak (2002) studied Cardiac aging. Aged mouse ventricular cardiac muscle cells vs. Young mouse ventricular cardiac muscle cells was evaluated on Aging-related changes of mRNA levels. Gene expression profiling of aged mouse cardiac myocytes revealed decreased cellular adaptation, reduced mitochondrial electron transport activity, and similarities with known heart disorders.
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