Key result
Large-scale gene expression profiling enables the identification of molecular pathways and regulatory events underlying changes in cardiac structure and function during senescence and disease.
Design
Review
Authors
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Hypothesis-generating for molecular mechanisms of age-related HF gene changes; clinical translation requires further study.
Large-scale gene expression profiling provides insights into the molecular mechanisms and pathways underlying aging-associated changes in cardiac structure and function, which are major risk factors for heart failure.
Volkova et al. (2004) conducted a review in Cardiovascular diseases and aging. Large-scale gene expression profiling enables the identification of molecular pathways and regulatory events underlying changes in cardiac structure and function during senescence and disease.
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