Why the study?
Despite endothelial cells playing critical roles in cardiovascular function and disease, the molecular impact of aging on this cell population in many organ systems remains unknown.
Population
Endothelial cells from heart, brain, and kidney of young (3 mo) and aged (24 mo) C57/BL6 mice
Comparison
Aged (24 mo) vs young (3 mo) mice
Design
Preclinical animal study
Authors
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Identifies age-related transcriptional changes in murine cardiac ECs; leaves open relevance to human cardiovascular aging.
Aging induces distinct transcriptional alterations in cardiac endothelial cells compared to other vascular beds, including a reduction in the Apelin Receptor-enriched subtype.
Emechebe et al. (2021) studied this question.
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