Key result
Single-cell transcriptional profiling of mouse endothelial cells revealed 590 and 252 differentially expressed genes between females and males at 3 and 18 months of age, respectively.
Why the study?
Although sex and age regulate endothelial cell function, their impact on endothelial cell gene expression had not been systematically analyzed at the single-cell level.
Population
Endothelial cells from five major organs in male and female C57BL/6 mice at 3 and 18 months of age
Comparison
Male vs female and 3-month vs 18-month age groups across five organs
Design
Single-cell transcriptional profiling study
Authors
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Animal EC transcriptomes should not alter clinical practice; leaves open cross-species validation for human cardiovascular aging.
Huang et al. (2021) studied Endothelial cell gene expression (n=13). Age and sex vs. Young and female mice was evaluated on Differentially expressed genes (DEGs) between males and females. Single-cell transcriptional profiling of mouse endothelial cells revealed 590 and 252 differentially expressed genes between females and males at 3 and 18 months of age, respectively.
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