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September 10, 2025Aging CellOpen Access

The Human Cardiac “Age‐OME”: Age‐Specific Changes in Myocardial Molecular Expression

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Authors

CMCassandra MaleckiBaird InstituteGGGiovanni GuglielmiBaird InstituteBHBenjamin HunterThe University of Sydney

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Overview

Omics analysis reveals age-related molecular changes in cardiac function, suggesting implications for heart disease.

Key Points

  • Older human hearts show downregulation of proteins linked to calcium signalling and contraction, affecting heart function.
  • Findings include dysregulation of glycolysis and increased long-chain fatty acids in aged hearts, impacting metabolism.
  • Omics analyses were conducted on pre-mortem, cryopreserved human heart tissues from younger and older individuals.
  • Understanding these age-related changes is crucial for developing strategies against age-related heart disease.

Cite This Study

Malecki et al. (2025) studied this question.

synapsesocial.com/papers/68c199e29b7b07f3a061b453https://doi.org/10.1111/acel.70219
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