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December 4, 2025The FASEB Journal

CDH11 Contributes to Airway Neutrophilic Inflammation in Severe Asthma via FGFR1

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Authors

HTHaixiong TangLFLin FuCYChangyun Yang

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Implication

Experimental analysis reveals CDH11 is linked to inflammation in severe asthma, suggesting potential therapeutic targets.

Key Points

  • Airway neutrophilic inflammation was significantly reduced by targeting CDH11, impacting IL-6 levels.
  • CDH11 expression was found elevated in severe asthma patients, particularly in bronchial tissues.
  • Inhibiting FGFR1 signaling decreased neutrophil recruitment in murine asthma models, highlighting a critical pathway.
  • Findings point to the importance of CDH11 in managing inflammation in severe asthma cases.

Cite This Study

Tang et al. (2025) studied this question.

synapsesocial.com/papers/6930e8d7ea1aef094cca3ae2https://doi.org/10.1096/fj.202501899rr
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